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樓主: 藥窕淑女

      
      		


      
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[驗證管理]
有獎討論：工藝驗證需要做壓片機速度的確認嗎？

      

 
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21#


      

      

      

      

发表于 2015-2-11 09:29:40
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飄過，不想多說，看了上面的，國內制藥還是參差不齊。
      



      

      

      


      



      

      


      

      

      		

      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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22#


      

      

      

      

发表于 2015-2-11 09:39:50
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驗證轉速的範圍。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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23#


      

      

      

      

发表于 2015-2-11 10:16:09
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如果不做，那壓片的速度怎麽來定，工藝難道不需要定壓片速度嗎？那員工怎麽操作
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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24#


      

      

      

      

发表于 2015-2-11 10:20:56
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再說就是工藝再驗證也要做，因爲設備通過多年的磨損是否能達到現在的要求
      



      

      

      


      



      

      


      

      

      		

      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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25#


      

      

      

      

 樓主|
发表于 2015-2-11 11:22:42
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      河西智叟 发表于 2015-2-10 19:50 
      
難道就沒人知道轉速和片子的硬度、外觀有直接的關系嗎？？？
      
难道就没人知道压片开始、中段、结束由于料斗 ...

      
壓片開始、中段、結束由于料鬥內顆粒重量的不同，這個應該不屬于混合物料的分層吧，只是一種物理現象，導致調整壓片速度。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      


      

      
 

      



      

      

      


      
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26#


      

      

      

      

 樓主|
发表于 2015-2-11 11:23:29
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      道路漫长黑暗 发表于 2015-2-10 20:21 
      
很重要，不同速度下片的受压时间不同，硬度脆碎重量差异等均有影响，最典型的例子，你把速度不断往上加最后 ...

      
速度越大，硬度越低，脆碎度越大嗎？
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      


      

      
 

      



      

      

      


      
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27#


      

      

      

      

 樓主|
发表于 2015-2-11 11:23:59
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      紅茶. 发表于 2015-2-11 08:09 
      
當然要，這麽關鍵的工藝參數竟然不做？

      
做了，想了解一下爲什麽要去做的。
      



      

      

      點評
      

      


      
片重，片重差異，硬度，脆碎度，崩解時限，溶出度，含量均勻度，每一項都與機速有莫大關系。 
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发表于 2015-2-11 11:51

      

      

      


      



      

      


      

      

      		

      

      

      





      

      





      

      


      

      
 

      



      

      

      


      
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28#


      

      

      

      

发表于 2015-2-11 11:51:03
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      藥窕淑女 发表于 2015-2-11 11:23 
      
做了，想了解一下爲什麽要去做的。

      
片重，片重差異，硬度，脆碎度，崩解時限，溶出度，含量均勻度，每一項都與機速有莫大關系。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      


      

      
 

      



      

      

      


      
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29#


      

      

      

      

发表于 2015-2-11 13:09:07
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這個跟你的工藝有關，你的工藝裏有轉速參數的要求那就必須得做，因爲要保證在合理的範圍內壓出的片子符合要要求
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      

      
      		


      


30#


      

      

      

      

发表于 2015-3-20 14:18:14
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不需要，閑的沒事也可以做
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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31#


      

      

      

      

发表于 2015-6-23 10:35:10
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老实的做吧  关键参数呀 不然你正常生产时怎么要求员工控制机器呢
      



      

      

      


      



      

      


      

      

      		

      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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32#


      

      

      

      

发表于 2015-6-23 10:49:45
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不同速度都去驗證不現實，國産設備我個人認爲設定其最大産能的八成運轉左右進行驗證，最大速度運行估計用不了三天就拜拜了。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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33#


      

      

      

      

发表于 2015-6-23 11:10:06
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個人認爲，壓片機種類與壓片速度範有關，如果壓片機是高速壓片機，可以正常開到30萬左右/小時的如果範爲正負2萬/小時，對片重差異，硬度，脆碎度，崩解時限，溶出度，含量均勻度影不大，不可能一影響也沒有，但是不容易發現差異。如果正負5萬/小時，最大與最小有所差異，但可壓性特別好的品種，也有可能差異也不大。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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34#


      

      

      

      

发表于 2015-6-23 11:47:43
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一般得做壓片速度上下限和一個工藝設定速度的片重差異、脆碎度，硬度，溶出度等吧？外觀嘛，一定檢查的咯，最基本檢查項之一。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      

      
      		


      


35#


      

      

      

      

发表于 2015-6-23 12:53:29
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不需要。。你工藝驗證是對已確定的工藝參數看其是否能滿足産品生産要求
      



      

      

      


      



      

      


      

      

      		

      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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36#


      

      

      

      

发表于 2015-6-23 12:57:35
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需要做，片重差異、崩解時限、脆碎度都與速度有較大關系。
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      


      
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37#


      

      

      

      

发表于 2015-6-23 13:13:24
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      河西智叟 发表于 2015-2-10 19:50 
      
難道就沒人知道轉速和片子的硬度、外觀有直接的關系嗎？？？
      
难道就没人知道压片开始、中段、结束由于料斗 ...

      
是有一定的道理，同意楼上的观点，转速和压力有一定的关系，还和填充量有一定的关系，是一系列的联系，比如~~在料斗满的情况下，物料填充好，速度控制在20转，压力调试，在料斗一半时，还按20转的话，会出现装量不稳，，一般轻了，  不稳之后会出现硬度不够...............实际干过的人应该明白~~~不过现在都是机械上料，验证得出片差、压力改变的临界点，可以机械控制  当料斗物料不足时会自动上料~~保证质量。。所以现在基本不存在那个问题，以前的设备 验证速度 还是很有必要的
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      


      

      
 

      



      

      

      

      
      		


      


38#


      

      

      

      

发表于 2015-7-17 10:57:02
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壓片機速度對片子的影響比較大，我覺得還是要做一下
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      

      
      		


      


39#


      

      

      

      

发表于 2015-7-20 08:50:46
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学习学习                 
      



      

      

      


      



      

      


      

      


      

      

      





      

      





      

      

      

      
 

      



      

      

      

      
      		


      


40#


      

      

      

      

发表于 2025-12-5 17:29:50
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可以做，如果中試做過了的話可以不做
      



      

      

      


      



      

      


      

      

      		

      

      

      





      

      





      

      

      

      



      






      






      



      

      

      

      








      

      

      


      

      
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 A JAPANESE AT HIS TOILET FOR A VISIT OF CEREMONY. A JAPANESE AT HIS TOILET FOR A VISIT OF CEREMONY. Top-side Galah! I prompted Camille to ask if he had ever encountered Ned Ferry, and he laughed. "But if she should be at Wiggins--" "And there is the whole trouble," I added. "She will not let you marry the woman whose--" A port crowded with steamers taking in coal, and very light barks high out of the water, kept in equilibrium by parallel outriggers at the ends of two flexible spars. These crank boats, made of[Pg 124] planks that scarcely overlap, were piled with luggage, and the boatmen jostle and turn and skim close under the fast-steaming transatlantic liners, amid a bewildering babel of shouts and oaths, under a sun hot enough to melt lead.     97 “You tell me who knew the way to get into the captain’s safe and I’ll try to get the emeralds.”  The reporter interposed that it was the act of men maddened by grief and their losses. [Pg 86] He turned his chair and studied her in a kind of hopeless amusement. "Felipa," he said, "if you will insist upon being told, I cut open the pockets of those dead men's clothes with it."  JOSIAH KLEGG, ESQ.,  "Did you raid the establishment of a person named"  "You drunken maverick," answered Billings, trying to brave it out. "I'll have you shot for insultin' and threatenin' your sooperior officer. Skip out o' here before the Provo comes up and ketches you. Let me go on about my business. Forward, boys."    "Of course you did. I—I gave myself away. I pleaded with you." That same day, Calverley summoned, or rather packed, a jury at which he himself presided; and a verdict of wilful murder was returned against Edith. Apprehensive, however, that the charge of poisoning might not be sustained upon the unsupported testimony of Mary Byles, he easily influenced the credulous jurors to believe that witchcraft had as much to do with the child's death as poison. His usual tact, however, had forsaken him on this occasion, and it was not until the verdict was announced and recorded, that the unwelcome conviction flashed across his mind, that the temporal courts could exercise no jurisdiction over the crime of witchcraft. It was now too late to alter the language of the inquisition. It had gone forth to hundreds who awaited its promulgation with intense anxiety; and the language of the verdict that "Edith Holgrave delivered to Mary Byles, a certain charmed or poisonous drug, for the purpose of destroying Roland De Boteler, and which said drug was administered to, and caused the death of, the said Roland," was, in a few hours, familiar to the whole town and neighbourhood.  Xi extends condolences over Hong Kong building fire, urges all-out rescue efforts to minimize losses
(Xinhua) 08:02, November 27, 2025
BEIJING, Nov. 26 (Xinhua) -- Chinese President Xi Jinping on Wednesday extended condolences over a deadly residential building fire in Hong Kong, which killed at least 13 people.

Xi, also general secretary of the Communist Party of China (CPC) Central Committee and chairman of the Central Military Commission, expressed sympathy to the families of the victims and those affected by the disaster. He urged all-out efforts to extinguish the fire and minimize casualties and losses.

In the wake of the fire, Xi attached great importance to the accident and immediately sought updates on the rescue efforts and casualties.

Xi instructed the director of the Liaison Office of the Central People's Government in the Hong Kong Special Administrative Region (HKSAR) to convey his condolences and sympathies to HKSAR Chief Executive John Lee.

He required the Hong Kong and Macao Work Office of the CPC Central Committee and the liaison office to support the HKSAR government in making all-out efforts to put out the fire, do everything possible in search and rescue, treat the injured, and comfort the victims' families.

(Web editor: Zhang Kaiwei, Du Mingming)
China releases white paper on arms control in new era
(Xinhua) 10:19, November 27, 2025
BEIJING, Nov. 27 (Xinhua) -- China's State Council Information Office on Thursday released a white paper titled "China's Arms Control, Disarmament, and Nonproliferation in the New Era."

The white paper said that China plays a constructive role in international arms control, disarmament, and nonproliferation, and actively offers its initiatives and solutions.

China has been and will always be a builder of world peace, a contributor to global development, and a defender of the international order, it said.

The white paper was released to comprehensively present China's policies and practices on arms control, disarmament, and nonproliferation, and its position on security governance in emerging fields such as outer space, cyberspace, and artificial intelligence.

It was also to restate China's commitment to safeguarding world peace and security, and to call on countries around the world to work together for international arms control.

The white paper noted that China is committed to upholding the international arms control regime with the United Nations (UN) at its core. It works to promote global governance in arms control, supports all efforts to build a world of lasting peace and common security, and serves as a key promoter of international arms control.

It also noted that as a permanent member of the UN Security Council, China has actively safeguarded the authority and effectiveness of the international arms control regime, played a constructive role in multilateral arms control in the nuclear, biological, chemical and other fields, and conscientiously performed its duties prescribed by international arms control treaties, making its due contribution to international arms control.

Emerging fields such as outer space, cyberspace, and AI represent new frontiers for human development. They create a new focus of strategic security, and new territories of global governance, the white paper pointed out.

China proposes that with the universal participation of all countries, the UN should play a pivotal role in fostering a global governance framework and standards for emerging fields based on broad consensus, while increasing the representation and voice of developing countries, it added.

The white paper stressed that China continues to build its domestic nonproliferation capacity, actively participating in the international nonproliferation process, promoting international cooperation on peaceful uses of science and technology, and facilitating the improvement of global nonproliferation governance.

Chinese modernization follows the path of peaceful development, and China's growth contributes to the growth of the world's peaceful forces. China stands ready to work with all peace-loving countries to build an equal and orderly multipolar world and promote universally beneficial and inclusive economic globalization. It will consolidate and develop the UN-centered international arms control regime, work with all parties to build a community with a shared future for humanity, and create a brighter future for all, according to the white paper.
The Chinese Foreign Ministry on Tuesday said the atmosphere of the phone call between Chinese President Xi Jinping and U.S. President Donald Trump on Monday was "positive, friendly, and constructive." 

At a regular press briefing on Tuesday, Foreign Ministry spokesperson Mao Ning confirmed that the U.S. side had initiated the call. She noted that since the start of President Trump's second term, the two leaders have maintained frequent communication. 

Mao said the two heads of state exchanged views on issues of mutual concern, stressing that such communication is vital for the stable development of China鈥揢.S. relations.
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