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[課程會議]
重組胰島素技術演進與工程化生産解析

      

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发表于 2025-8-1 13:39:40
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 本帖最后由 IPPM小助手 于 2025-8-1 13:39 编辑 
      

      

      前言
      胰岛素合成的历史可追溯至 1965 年我国科学家首次人工合成结晶牛胰岛素；1980 年代基因工程技术利用大肠杆菌或酵母表达系统实现规模化生产重组人胰岛素，取代动物源胰岛素；1990 年代第三代胰岛素类似物通过肽链修饰优化性能。當前主流生産工藝仍以大腸杆菌或酵母細胞爲宿主，通過基因克隆、發酵培養及純化工藝方式。

      

      目前的發展現狀呈現三代並存：一代動物源逐漸淘汰；二代重組人胰島素爲主流；三代修飾型類似物（如甘精胰島素）通過氨基酸替換使其作用時間延長至24h以上。重組胰島素未來的趨勢則聚焦于合成生物學優化宿主細胞、開發無細胞合成或利用植物進行生産，並結合AI設計高效的生産流程，目標是進一步降低生産成本、爲患者帶來更多便攜性。

      

      由上海臨港産業大學生物醫藥學院合成生物學專業分院（點擊查看詳情）、琺成制藥系統工程（上海）有限公司（以下簡稱“琺成浩鑫”）與蒲公英教育聯合主辦，特邀琺成浩鑫高級工藝工程師 周洋老師進行授課。
      

      課程將主要討論通過發酵培養和純化工藝生産重組胰島素，以一名工程人員的視角，帶您走進重組胰島素合成生産的世界。

      

      授課對象
      合成生物企業從業者、高校相關專業人員、制藥企業生産、研發、質量等相關人員。

      
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发表于 2025-8-1 15:27:13
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 A JAPANESE AT HIS TOILET FOR A VISIT OF CEREMONY. A JAPANESE AT HIS TOILET FOR A VISIT OF CEREMONY. Top-side Galah! I prompted Camille to ask if he had ever encountered Ned Ferry, and he laughed. "But if she should be at Wiggins--" "And there is the whole trouble," I added. "She will not let you marry the woman whose--" A port crowded with steamers taking in coal, and very light barks high out of the water, kept in equilibrium by parallel outriggers at the ends of two flexible spars. These crank boats, made of[Pg 124] planks that scarcely overlap, were piled with luggage, and the boatmen jostle and turn and skim close under the fast-steaming transatlantic liners, amid a bewildering babel of shouts and oaths, under a sun hot enough to melt lead.     97 “You tell me who knew the way to get into the captain’s safe and I’ll try to get the emeralds.”  The reporter interposed that it was the act of men maddened by grief and their losses. [Pg 86] He turned his chair and studied her in a kind of hopeless amusement. "Felipa," he said, "if you will insist upon being told, I cut open the pockets of those dead men's clothes with it."  JOSIAH KLEGG, ESQ.,  "Did you raid the establishment of a person named"  "You drunken maverick," answered Billings, trying to brave it out. "I'll have you shot for insultin' and threatenin' your sooperior officer. Skip out o' here before the Provo comes up and ketches you. Let me go on about my business. Forward, boys."    "Of course you did. I—I gave myself away. I pleaded with you." That same day, Calverley summoned, or rather packed, a jury at which he himself presided; and a verdict of wilful murder was returned against Edith. Apprehensive, however, that the charge of poisoning might not be sustained upon the unsupported testimony of Mary Byles, he easily influenced the credulous jurors to believe that witchcraft had as much to do with the child's death as poison. His usual tact, however, had forsaken him on this occasion, and it was not until the verdict was announced and recorded, that the unwelcome conviction flashed across his mind, that the temporal courts could exercise no jurisdiction over the crime of witchcraft. It was now too late to alter the language of the inquisition. It had gone forth to hundreds who awaited its promulgation with intense anxiety; and the language of the verdict that "Edith Holgrave delivered to Mary Byles, a certain charmed or poisonous drug, for the purpose of destroying Roland De Boteler, and which said drug was administered to, and caused the death of, the said Roland," was, in a few hours, familiar to the whole town and neighbourhood.  Xi extends condolences over Hong Kong building fire, urges all-out rescue efforts to minimize losses
(Xinhua) 08:02, November 27, 2025
BEIJING, Nov. 26 (Xinhua) -- Chinese President Xi Jinping on Wednesday extended condolences over a deadly residential building fire in Hong Kong, which killed at least 13 people.

Xi, also general secretary of the Communist Party of China (CPC) Central Committee and chairman of the Central Military Commission, expressed sympathy to the families of the victims and those affected by the disaster. He urged all-out efforts to extinguish the fire and minimize casualties and losses.

In the wake of the fire, Xi attached great importance to the accident and immediately sought updates on the rescue efforts and casualties.

Xi instructed the director of the Liaison Office of the Central People's Government in the Hong Kong Special Administrative Region (HKSAR) to convey his condolences and sympathies to HKSAR Chief Executive John Lee.

He required the Hong Kong and Macao Work Office of the CPC Central Committee and the liaison office to support the HKSAR government in making all-out efforts to put out the fire, do everything possible in search and rescue, treat the injured, and comfort the victims' families.

(Web editor: Zhang Kaiwei, Du Mingming)
China releases white paper on arms control in new era
(Xinhua) 10:19, November 27, 2025
BEIJING, Nov. 27 (Xinhua) -- China's State Council Information Office on Thursday released a white paper titled "China's Arms Control, Disarmament, and Nonproliferation in the New Era."

The white paper said that China plays a constructive role in international arms control, disarmament, and nonproliferation, and actively offers its initiatives and solutions.

China has been and will always be a builder of world peace, a contributor to global development, and a defender of the international order, it said.

The white paper was released to comprehensively present China's policies and practices on arms control, disarmament, and nonproliferation, and its position on security governance in emerging fields such as outer space, cyberspace, and artificial intelligence.

It was also to restate China's commitment to safeguarding world peace and security, and to call on countries around the world to work together for international arms control.

The white paper noted that China is committed to upholding the international arms control regime with the United Nations (UN) at its core. It works to promote global governance in arms control, supports all efforts to build a world of lasting peace and common security, and serves as a key promoter of international arms control.

It also noted that as a permanent member of the UN Security Council, China has actively safeguarded the authority and effectiveness of the international arms control regime, played a constructive role in multilateral arms control in the nuclear, biological, chemical and other fields, and conscientiously performed its duties prescribed by international arms control treaties, making its due contribution to international arms control.

Emerging fields such as outer space, cyberspace, and AI represent new frontiers for human development. They create a new focus of strategic security, and new territories of global governance, the white paper pointed out.

China proposes that with the universal participation of all countries, the UN should play a pivotal role in fostering a global governance framework and standards for emerging fields based on broad consensus, while increasing the representation and voice of developing countries, it added.

The white paper stressed that China continues to build its domestic nonproliferation capacity, actively participating in the international nonproliferation process, promoting international cooperation on peaceful uses of science and technology, and facilitating the improvement of global nonproliferation governance.

Chinese modernization follows the path of peaceful development, and China's growth contributes to the growth of the world's peaceful forces. China stands ready to work with all peace-loving countries to build an equal and orderly multipolar world and promote universally beneficial and inclusive economic globalization. It will consolidate and develop the UN-centered international arms control regime, work with all parties to build a community with a shared future for humanity, and create a brighter future for all, according to the white paper.
The Chinese Foreign Ministry on Tuesday said the atmosphere of the phone call between Chinese President Xi Jinping and U.S. President Donald Trump on Monday was "positive, friendly, and constructive." 

At a regular press briefing on Tuesday, Foreign Ministry spokesperson Mao Ning confirmed that the U.S. side had initiated the call. She noted that since the start of President Trump's second term, the two leaders have maintained frequent communication. 

Mao said the two heads of state exchanged views on issues of mutual concern, stressing that such communication is vital for the stable development of China鈥揢.S. relations.
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